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Nalmefene HCl Essentials

HELP TAKE CONTROL OF OPIOID OVERDOSE UNKNOWNS WITH NALMEFENE HCl

Effectively reversed respiratory depression within 2 to 5 minutes in most patients1†

10.8-hour mean terminal elimination half-life1‡

Safety and tolerability similar to naloxone1

Flexibility to be given as IV, IM, or SC injection1

IM=intramuscular; IV=intravenous; SC=subcutaneous.

†

Studied in 284 patients presumed to have taken an opioid overdose. Effectively reversed respiratory depression at doses of 0.5 mg to 1 mg. Dose range in clinical trials was 0.5 mg to 2 mg.1,2

‡

Nalmefene elimination half-life is based on pharmacokinetic data. The mean terminal elimination half-life is 10.8 hours and 9.4 hours in younger (19 to 32 years) and elderly (62 to 80 years) healthy male subjects, respectively, following a Nalmefene HCl 1 mg IV dose.1